BDNF (I)rising from exercise.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24206660.
- Also identified by DOI 10.1016/j.cmet.2013.10.008 and PMC identifier 3951409.
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Abstract
Exercise produces many beneficial effects on brain health, in part by increasing hippocampal BDNF levels; however, the mechanism underlying BDNF gene regulation remains unknown. In this issue of Cell Metabolism, Wrann et al. (2013) show that exercise induces hippocampal Bdnf expression by stimulating expression of FNDC5, the precursor of irisin, via the transcriptional complex PGC-1α/Errα.
Medical subject headings
- Brain-Derived Neurotrophic Factor
- Fibronectins
- Hippocampus
- Physical Conditioning, Animal
- Signal Transduction
- Transcription Factors