Interleukins and atherosclerosis: a dysfunctional family grows.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24206661.
- Also identified by DOI 10.1016/j.cmet.2013.10.009 and PMC identifier 3869622.
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Abstract
Atherosclerosis is driven by the release of cytokines from macrophages, and the β isoform of interleukin-1 (IL-1β) is a prime suspect in disease progression. Freigang et al. (2013) now suggest that IL-1α, a close relative, is selectively induced by fatty acids independent of the inflammasome to promote vascular inflammation.
Medical subject headings
- Atherosclerosis
- Fatty Acids
- Inflammasomes
- Interleukin-1alpha
- Mitochondria
- Vasculitis