Comparison of frozen and unfrozen blood spots for gene expression studies.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 24209717.
- Also identified by DOI 10.1016/j.jpeds.2013.09.025 and PMC identifier 4326080.
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Abstract
We studied gene expression in 9 sets of paired newborn blood spots stored for 8-10 years in either the frozen state or the unfrozen state. Fewer genes were expressed in unfrozen spots, but the average correlation coefficient for overall gene expression comparing the frozen and unfrozen state was 0.771 (95% CI, 0.700-0.828).
Medical subject headings
- Cryopreservation
- Freezing
- Gene Expression Profiling
- Neonatal Screening
- Oligonucleotide Array Sequence Analysis
- RNA, Messenger