Trivalent chromatin marks the way in.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24209756.
- Also identified by DOI 10.1016/j.stem.2013.10.007 and PMC identifier 4665996.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Recently in Cell, Wapinski et al. (2013) investigated the epigenetic mechanisms underlying the direct conversion of fibroblasts to induced neurons (iNs). They found that Ascl1 acts as a pioneer factor at neurogenic loci marked by a closed "trivalent" chromatin state in cells permissive to direct conversion, but not in restrictive cell types.
Medical subject headings
- Cellular Reprogramming
- Embryo, Mammalian
- Fibroblasts
- Gene Regulatory Networks
- Neurons