Responding to R-spondin: slit2 potentiates intestinal regeneration.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24209757.
- Also identified by DOI 10.1016/j.stem.2013.10.006.
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Abstract
Gastrointestinal toxicity of chemoradiotherapy treatment in late-stage cancer patients limits tolerable doses and effectiveness of treatments. Zhou and colleagues in Nature (Zhou et al., 2013) suggest that activating Robo/Slit signaling in concert with R-Spondin potentiates Wnt signaling in intestinal stem cells and drives successful intestinal regeneration and recovery.
Medical subject headings
- Intercellular Signaling Peptides and Proteins
- Intestines
- Neoplasms
- Nerve Tissue Proteins
- Stem Cells
- Thrombospondins