The gut microbiome as novel cardio-metabolic target: the time has come!
review · Level V
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- Record sourced from PubMed, PMID 24216389.
- Also identified by DOI 10.1093/eurheartj/eht467 and PMC identifier 3977135.
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Abstract
Recent studies reveal a potential contribution of intestinal microbes in the expression of certain human cardio-metabolic diseases. The mechanisms through which intestinal microbiota and/or their metabolic products alter systemic homoeostasis and cardio-metabolic disease risks are just beginning to be dissected. Intervention studies in humans aiming to either selectively alter the composition of the intestinal microbiota or to pharmacologically manipulate the microbiota to influence production of their metabolites are crucial next steps. The intestinal microbiome represents a new potential therapeutic target for the treatment of cardio-metabolic diseases.
Medical subject headings
- Gastrointestinal Tract
- Microbiota