Transient dynamics of an elastic capsule in a microfluidic constriction.

Abstract

In this paper we investigate computationally the transient dynamics of an elastic capsule flowing in a square microchannel with a rectangular constriction, and compare it with that of a droplet. The confinement and expansion dynamics of the fluid flow results in a rich deformation behavior for the capsule, from an elongated shape at the constriction entrance, to a flattened parachute shape at its exit. Larger capsules are shown to take more time to pass the constriction and cause higher additional pressure difference, owing to higher flow blocking. Our work highlights the effects of two different mechanisms for non-tank-treading transient capsule dynamics. The capsule deformation results from the combined effects of the surrounding and inner fluids' normal stresses on the soft particle's interface, and thus when the capsule viscosity increases, its transient deformation decreases, as for droplets. However, the capsule deformation is not able to create a strong enough inner circulation (owing to restrictions imposed by the material membrane), and thus the viscosity ratio does not affect much the capsule velocity and the additional pressure difference. In addition, the weak inner circulation results in a positive additional pressure difference Δ<i>P</i>⁺ even for low-viscosity capsules, in direct contrast to low-viscosity droplets which create a negative Δ<i>P</i>⁺. Our findings suggest that the high cytoplasmatic viscosity, owing to the protein hemoglobin required for oxygen transport, does not affect adversely the motion of non-tank-trading erythrocytes in vascular capillaries.