Stochastic fate selection in HIV-infected patients.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24243007.
- Also identified by DOI 10.1016/j.cell.2013.09.039.
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Abstract
Classic studies proposed that stochastic variability ("noise") can drive biological fate switching, enhancing evolutionary success. Now, Ho et al. report that HIV's reactivation from dormant (latently infected) patient cells-the major barrier to an HIV cure-is inherently stochastic. Eradicating an incompletely inducible (probabilistic) viral phenotype will require inventive approaches.
Medical subject headings
- HIV Infections
- HIV-1
- Virus Latency