Fe-salphen complexes from intracellular pH-triggered degradation of Fe3O4@Salphen-InIII CPPs for selectively killing cancer cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24246644.
- Also identified by DOI 10.1016/j.biomaterials.2013.10.081.
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Abstract
We propose a modular synthetic strategy to constitute metallosalphen prodrugs in the form of coordination polymer nanoparticles, comprising magnetite nanocrystal colloidal cluster as core and salphen-In(III) coordination polymer as shell. These composite nanoparticles are not only equipped with intense photoluminescence, sensitive magnetic responsiveness and pH-dependent degradability, but also serve as prodrugs to accomplish intercellular conversion from non-toxic nanoparticles (Fe3O4@Salphen-In(III)) to pharmacologically active complexes (Fe-salphen), allowing to specifically inhibit the proliferation of A549 cancer cells via caspase activation.
Medical subject headings
- Ferric Compounds
- Hydrogen-Ion Concentration
- Neoplasms
- Phenylenediamines