Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24248369.
- Also identified by DOI 10.1073/pnas.1320118110 and PMC identifier 3856836.
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Abstract
Mycobacterium tuberculosis (Mtb) restrains immune responses well enough to escape eradication but elicits enough immunopathology to ensure its transmission. Here we provide evidence that this host-pathogen relationship is regulated in part by a cytosolic, membrane-associated protein with a unique structural fold, encoded by the Mtb gene rv0431. The protein acts by regulating the quantity of Mtb-derived membrane vesicles bearing Toll-like receptor 2 ligands, including the lipoproteins LpqH and SodC. We propose that rv0431 be named "vesiculogenesis and immune response regulator."
Medical subject headings
- Bacterial Proteins
- Immunomodulation
- Lipoproteins
- Membrane Proteins
- Models, Molecular
- Mycobacterium tuberculosis
- Transport Vesicles