Mitochondrial 12S ribosomal RNA A1555G mutation associated with cardiomyopathy and hearing loss following high-dose chemotherapy and repeated aminoglycoside exposure.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 24252789.
- Also identified by DOI 10.1016/j.jpeds.2013.10.024.
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Abstract
A 19-month-old girl with the A1555G mitochondrial mutation in the 12S ribosomal RNA gene and acute myelogenous leukemia developed dilated cardiomyopathy and bilateral sensorineural hearing loss before undergoing allogeneic stem cell transplantation. She had received gentamicin during episodes of febrile neutropenia. Testing for the A1555G mutation is recommended in patients frequently treated with aminoglycosides.
Medical subject headings
- Aminoglycosides
- Cardiomyopathies
- Hearing Loss, Sensorineural
- Mutation
- RNA, Ribosomal