Naked replication forks break apRPArt.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24267882.
- Also identified by DOI 10.1016/j.cell.2013.10.049 and PMC identifier 6589161.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Stalled replication forks occasionally collapse, leading to potentially catastrophic DNA double-strand breaks. Now, Toledo et al. (2013) reveal that fork breakage occurs when the pool of the single-strand DNA-binding protein RPA becomes exhausted. This study has important implications for the origin and treatment of cancers with high levels of replicative stress.
Medical subject headings
- DNA Replication
- Genomic Instability
- Replication Protein A