Incident herpes simplex virus type 2 infection increases the risk of subsequent episodes of bacterial vaginosis.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 24273042.
- Also identified by DOI 10.1093/infdis/jit634 and PMC identifier 3952675.
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Abstract
Herpes simplex virus type 2 (HSV-2) infected women have a higher prevalence of bacterial vaginosis (BV) compared to HSV-2-seronegative women. To explore the temporal association between these conditions, we evaluated the frequency of BV episodes before and after HSV-2 acquisition in a prospective study of 406 HSV-2/HIV-1-seronegative Kenyan women, of whom 164 acquired HSV-2. Incident HSV-2 was associated with increased likelihood of BV (adjusted OR, 1.28; 95% CI, 1.05-1.56; P = .01). Our findings strengthen the evidence for a causal link between genital HSV-2 infection and disruption of the vaginal microbiota.
Medical subject headings
- Herpes Genitalis
- Herpesvirus 2, Human
- Vaginosis, Bacterial