Fos-icking for control of angiogenesis: increasing the longevity of peritoneal dialysis.

Abstract

Recurring peritonitis reduces the effectiveness of peritoneal dialysis by increasing fibrosis and angiogenesis, ultimately causing ultrafiltration failure (UFF). Identifying the processes underlying UFF will provide new hope for patients with chronic kidney disease. Catar and colleagues demonstrate that transforming growth factor-β, tumor necrosis factor-α, and interleukin-1 synergize to significantly increase the production and release of vascular endothelial growth factor by mesothelial cells, which, if untreated, will promote peritoneal angiogenesis, leading to UFF.