JC viruria and kidney disease in APOL1 risk genotype individuals: is this a clue to a gene × environment interaction?
Level V
Where this comes from
- Record sourced from PubMed, PMID 24280748.
- Also identified by DOI 10.1038/ki.2013.299 and PMC identifier 6108437.
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Abstract
APOL1 nephropathy occurs in a minority of genetically at-risk individuals, suggesting that other factors, such as other genes or environmental factors, contribute. Divers and colleagues report that among individuals with two APOL1 risk alleles, those with JC viruria are less likely to manifest kidney disease compared with those lacking JC viruria. These data might suggest that JC virus infection confers protection against glomerular injury, perhaps by altering cell function or generating immunity against a related polyomavirus.
Medical subject headings
- Black or African American
- Apolipoproteins
- JC Virus
- Kidney Diseases
- Lipoproteins, HDL
- Polyomavirus Infections
- Tumor Virus Infections