Alloreactive T cells and 'the persistence of memory'.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24280750.
- Also identified by DOI 10.1038/ki.2013.295.
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Abstract
Circulating donor-reactive effector memory T cells have been associated with allograft injury in humans. The next step to translate this observation into clinical practice is the design of clinical trials aimed at individualization of T cell-targeted therapy. The administration of immunosuppressive therapy based on the presence or absence of donor-reactive effector memory T cells could influence clinical outcomes, but independent of such therapy, when 'the persistence of memory' prevails, allograft injury may occur.
Medical subject headings
- Graft Rejection
- Graft Survival
- Immunity, Cellular
- Immunologic Memory
- Immunosuppressive Agents
- Isoantigens
- Kidney Transplantation
- T-Lymphocytes