Inconsistency in large pharmacogenomic studies.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24284626.
- Also identified by DOI 10.1038/nature12831 and PMC identifier 4237165.
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Abstract
Two large-scale pharmacogenomic studies were published recently in this journal. Genomic data are well correlated between studies; however, the measured drug response data are highly discordant. Although the source of inconsistencies remains uncertain, it has potential implications for using these outcome measures to assess gene-drug associations or select potential anticancer drugs on the basis of their reported results.
Medical subject headings
- Antineoplastic Agents
- Pharmacogenetics