Mechanically driven accumulation of microscale material at coupled solid-fluid interfaces in biological channels.

Abstract

The accumulation of microscale materials at solid-fluid interfaces in biological channels is often the initial stage of certain growth processes, which are present in some forms of atherosclerosis. The objective of this work is to develop a relatively simple model for such accumulation, which researchers can use to qualitatively guide their analyses. Specifically, the approach is to construct rate equations for the accumulation at the solid-fluid interface as a function of the intensity of the shear stress. The accumulation of material subsequently reduces the cross-sectional area of the channel until the fluid-induced shear stress at the solid-fluid interface reaches a critical value, which terminates the accumulation rate. Characteristics of the model are explored analytically and numerically.