The role of oxidative stress in aseptic loosening of total hip arthroplasties.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24290740.
- Also identified by DOI 10.1016/j.arth.2013.09.001 and PMC identifier 3965616.
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Abstract
This study investigated the hypothesis that wear particle-induced oxidative stress initiates osteolysis after total hip arthroplasty (THA). Patient radiographs were scored for osteolysis and periprosthetic tissues were immunostained and imaged to quantify polyethylene wear, inflammation, and five osteoinflammatory and oxidative stress-responsive factors. These included high mobility group protein-B1 (HMGB1), cyclooxygenase-2 (COX2), inducible nitric oxide synthase (iNOS), 4-hydroxynonenal (4-HNE), and nitrotyrosine (NT). The results show wear debris correlated with inflammation, 4-HNE, NT and HMGB1, whereas inflammation only correlated with NT and HMGB1. Similar to wear debris and inflammation, osteolysis correlated with HMGB1. Additionally, osteolysis correlated with COX2 and 4-HNE, but not iNOS or NT. Understanding the involvement of oxidative stress in wear-induced osteolysis will help identify diagnostic biomarkers and therapeutic targets to prevent osteolysis after THA.
Medical subject headings
- Arthroplasty, Replacement, Hip
- Hip Prosthesis
- Osteolysis
- Oxidative Stress
- Prosthesis Failure
Anatomy
- hip