In vivo discography in degenerate porcine spines revealed pressure transfer to adjacent discs.

Abstract

In vivo experimental porcine study. To investigate if discography induced pressure increase in adjacent degenerate discs. Despite refinements in the past 2 decades, the validity of discography is debated. Discography in healthy pigs has shown that the pressure increase during disc injection transmits to adjacent discs, a potential source for false positive responses. Degeneration in 1 lumbar disc was induced in 10 pigs by drilling a hole through the endplate. Intradiscal pressure was recorded using a 0.36-mm fiber-optic pressure transducer inserted into nucleus pulposus through a 22-gauge needle. The pressure was measured simultaneously in 2 adjacent discs during slow (0.03 mL/s) automated contrast injection into 1 of the discs up to 8 bar (116 psi). Ten adjacent discs were prefilled with contrast from previous discogram. A pressure increase 2 psi or more above baseline was defined as increased pressure in adjacent discs. Pressure was recorded until 15 minutes after injection. A total of 28 discograms were successfully performed. A pressure increase during injection was detected in 57% (16) of the 28 adjacent discs with mean 3.2 psi (1.7-8.2; standard deviation, 1.8), corresponding to a mean increase above baseline of 11%. Of those 16 adjacent discs, 4 were nondegenerate and 12 degenerate, of which 7 were prefilled. Fifteen minutes after injection, 89% of adjacent discs displayed increase in pressure of mean 14% above baseline. Discography induced pressure increase in adjacent discs in a degenerate disc model, something not reported earlier. If present, also in human spine pressure transmission, may be a potential cause for false positive discography responses.