A novel site comes into sight.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24302574.
- Also identified by DOI 10.7554/eLife.01680 and PMC identifier 3847883.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Oxysterols modulate the Hedgehog signalling pathway by binding a novel site on the membrane protein Smoothened, which may offer new options for the treatment of cancers linked to this pathway.
Medical subject headings
- Hedgehog Proteins
- Receptors, G-Protein-Coupled
- Sterols
- Zebrafish
- Zebrafish Proteins