Detection of single nanoparticles and lentiviruses using microcavity resonance broadening.

Shao, Linbo; Jiang, Xue-Feng; Yu, Xiao-Chong; Li, Bei-Bei; Clements, William R; Vollmer, Frank; Wang, Wei; Xiao, Yun-Feng et al. · Adv Mater · 2013

basic_science · Level V

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Abstract

A new label-free sensing mechanism is demonstrated experimentally by monitoring the whispering-gallery mode broadening in microcavities. It is immune to both noise from the probe laser and environmental disturbances, and is able to remove the strict requirement for ultra-high-Q mode cavities for sensitive nanoparticle detection. This ability to sense nanoscale objects and biological analytes is particularly crucial for wide applications.

Medical subject headings