Structure modeling using genetically engineered crosslinking.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24315089.
- Also identified by DOI 10.1016/j.cell.2013.11.018.
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Abstract
Class B G-protein-coupled receptors are exciting drug targets, yet the structure of a complete receptor bound to a peptide agonist has remained elusive. Coin et al. present a model of the receptor CRF1R bound to its native ligand based on partial structures and 44 spatial constraints revealed by new crosslinking approaches.
Medical subject headings
- Models, Molecular
- Receptors, Corticotropin-Releasing Hormone
- Urocortins