Trp'ing tuberculosis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24315090.
- Also identified by DOI 10.1016/j.cell.2013.11.015.
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Abstract
IFN-γ-activated macrophages attempt to limit pathogen growth through tryptophan starvation. Zhang et al. demonstrate that Mycobacterium tuberculosis responds to this threat by synthesizing its own tryptophan. Genetic and chemical inhibition of this pathway reduces mycobacterial survival, revealing a new immune-dependent drug target for tuberculosis.
Medical subject headings
- CD4-Positive T-Lymphocytes
- Mycobacterium tuberculosis
- Tryptophan
- Tuberculosis