snRNA catalysts in the spliceosome's ancient core.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24315092.
- Also identified by DOI 10.1016/j.cell.2013.11.022 and PMC identifier 4162089.
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Abstract
The spliceosome, an assembly of snRNAs and proteins, catalyzes the removal of introns from premessenger RNAs. A new study identifies specific phosphates in the U2-U6 snRNA complex that position two catalytic metals. Remarkably, these correspond precisely to metal-binding phosphates in a homologous structure of Group II self-splicing introns, long proposed to be the ribozyme progenitor of spliceosome.
Medical subject headings
- RNA Precursors
- RNA Splicing
- RNA, Small Nuclear
- Saccharomyces cerevisiae