Autophagy-mediated tumor promotion.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24315093.
- Also identified by DOI 10.1016/j.cell.2013.11.019 and PMC identifier 3987898.
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Abstract
Mouse models for cancer are revealing novel cancer-promoting roles for autophagy. Autophagy promotes tumor growth by suppressing the p53 response, maintaining mitochondrial function, sustaining metabolic homeostasis and survival in stress, and preventing diversion of tumor progression to benign oncocytomas.
Medical subject headings
- Autophagy
- Carcinogenesis
- Neoplasms