Proteostasis impairment: at the intersection between Alzheimer's disease and diabetes.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24315366.
- Also identified by DOI 10.1016/j.cmet.2013.11.009.
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Abstract
Altered insulin signaling and neuroinflammation are emerging features of Alzheimer's disease. Lourenco et al. (2013) identify a pathogenic mechanism that is shared between Alzheimer's disease and diabetes and contributes to memory loss through a common molecular event: the control of protein synthesis by PKR and the downstream phosphorylation of eIF2α.
Medical subject headings
- Amyloid beta-Peptides
- Brain
- Insulin Receptor Substrate Proteins
- Polymers
- Tumor Necrosis Factor-alpha
- eIF-2 Kinase