Does reduced creatine synthesis protect against statin myopathy?
Level V
Where this comes from
- Record sourced from PubMed, PMID 24315367.
- Also identified by DOI 10.1016/j.cmet.2013.11.012 and PMC identifier 3899594.
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Abstract
Statins, widely used to lower cholesterol levels, cause myopathy in some patients. Mangravite et al. (2013) show that a single nucleotide polymorphism decreasing expression of glycine amidinotransferase (GATM), the enzyme regulating creatine biosynthesis, is associated with reduced statin myopathy. Whether reduced creatine production protects against statin myopathy remains to be determined.
Medical subject headings
- Amidinotransferases
- Gene Expression Regulation
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Muscular Diseases
- Quantitative Trait Loci
- Simvastatin