Inducing cellular aging: enabling neurodegeneration-in-a-dish.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24315433.
- Also identified by DOI 10.1016/j.stem.2013.11.017 and PMC identifier 3908665.
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Abstract
The immaturity of neurons differentiated from human induced pluripotent stem cells (hiPSCs) presents difficulties for modeling late-onset neurodegenerative disorders such as Parkinson's disease. Now, Miller et al. (2013) provide a strategy for inducing aging-related phenotypes in hiPSC-derived neurons, enabling in vitro study of late-onset neurodegenerative diseases.
Medical subject headings
- Aging
- Induced Pluripotent Stem Cells
- Models, Biological
- Nuclear Proteins
- Protein Precursors