Who needs stem cells if you can dedifferentiate?
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 24315436.
- Also identified by DOI 10.1016/j.stem.2013.11.020.
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Abstract
Regenerative mechanisms involving either stem cell differentiation or dedifferentiation of mature cells have been described in various systems, but the relationship between such disparate mechanisms is unclear. Two recent papers, one by Sandoval-Guzmán et al. (2013) and one by Tata et al. (2013), address fundamental questions about the universality of reparative regeneration and whether mammals share any properties seen in lower vertebrates.