Noncanonical Wnt comes of age in hematopoietic stem cells.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24315437.
- Also identified by DOI 10.1016/j.stem.2013.11.009.
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Abstract
Understanding molecular mechanisms of aging is crucial in efforts to reverse it. In a recent issue of Nature, Florian et al. (2013) report that increasing levels of noncanonical Wnt signaling accompany hematopoietic stem cell (HSC) aging, which can be modulated to functionally rejuvenate HSCs.
Medical subject headings
- Cellular Senescence
- Hematopoietic Stem Cells
- Wnt Signaling Pathway