Child neurology: differential diagnosis of a low CSF glucose in children and young adults.

Leen, Wilhelmina G; de Wit, Cornelis J; Wevers, Ron A; van Engelen, Baziel G; Kamsteeg, Erik-Jan; Klepper, Joerg; Verbeek, Marcel M; Willemsen, Michèl A · Neurology · 2013

review · Level V

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Abstract

Analysis of CSF is daily routine in patients with acute neurologic disorders like CNS infections. In those patients, the finding of a low CSF glucose may influence further diagnostic workup and therapeutic choices. The interpretation of a low CSF glucose in patients with a chronic neurologic disorder, however, is a less common practice. We present a practical overview on the differential diagnosis of a low CSF glucose and stress the importance of recognizing a low CSF glucose as the diagnostic marker for GLUT1 deficiency syndrome, a treatable neurometabolic disorder.

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