ChAMP: 450k Chip Analysis Methylation Pipeline.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24336642.
- Also identified by DOI 10.1093/bioinformatics/btt684 and PMC identifier 3904520.
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Abstract
The Illumina Infinium HumanMethylation450 BeadChip is a new platform for high-throughput DNA methylation analysis. Several methods for normalization and processing of these data have been published recently. Here we present an integrated analysis pipeline offering a choice of the most popular normalization methods while also introducing new methods for calling differentially methylated regions and detecting copy number aberrations. ChAMP is implemented as a Bioconductor package in R. The package and the vignette can be downloaded at bioconductor.org
Medical subject headings
- DNA Methylation
- Oligonucleotide Array Sequence Analysis
- Software