Rituximab as successful adjunct treatment in a patient with disseminated nontuberculous mycobacterial infection due to acquired anti-interferon-γ autoantibody.
case_report · Level V
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- Record sourced from PubMed, PMID 24336756.
- Also identified by DOI 10.1093/cid/cit809 and PMC identifier 3935498.
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Abstract
An acquired immune deficiency due to interferon gamma (IFN-γ) autoantibodies was diagnosed in a 78-year-old Japanese man with treatment-refractory disseminated nontuberculous mycobacterial infection. In addition to standard antimycobacterial therapy, he was successfully treated with rituximab to eliminate B cells and thereby the autoantibody. Subsequently, he obtained a sustained remission from infection.
Medical subject headings
- Antibodies, Monoclonal, Murine-Derived
- Autoantibodies
- Immunologic Factors
- Interferon-gamma
- Mycobacterium Infections, Nontuberculous