Rational design of polyion complex nanoparticles to overcome cisplatin resistance in cancer therapy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24338636.
- Also identified by DOI 10.1002/adma.201303360.
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Abstract
Rationally designed PIC nanoparticles as next-generation delivery system: we have developed a core-shell-corona PIC nanoparticle (⊕) NP/Pt@PPC-DA as a next-generation delivery system. (⊕) NP/Pt@PPC-DA exhibits prolonged circulation and enhanced drug accumulation in tumors. Subsequently, tumor pH leads to the release of (⊕) NP/Pt, which facilitates cellular uptake followed by rapid intracellular cisplatin release. Using this delivery strategy cisplatin-resistant tumor growth in a murine xenograft model has been successfully suppressed.
Medical subject headings
- Antineoplastic Agents
- Cisplatin
- Drug Resistance, Neoplasm
- Nanoconjugates