Multicellular assembly and light-regulation of cell-cell communication by conjugated polymer materials.

Wang, Bing; Song, Jinzhao; Yuan, Huanxiang; Nie, Chenyao; Lv, Fengting; Liu, Libing; Wang, Shu · Adv Mater · 2014

basic_science · Level V

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Abstract

Using cell-surface modification and biotin-streptavidin interactions, immune cells and target tumor cells are made to form multicellular assemblies. A polythiophene derivative can undergo cellular uptake, allowing the sensitization of oxygen under light irradiation. The subsequent generation of reactive oxygen species (ROS) regulates cell-cell communication in time and space.

Medical subject headings