Tunable delivery of siRNA from a biodegradable scaffold to promote angiogenesis in vivo.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24338842.
- Also identified by DOI 10.1002/adma.201303520 and PMC identifier 3951880.
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Abstract
<b>A system has been engineered for temporally controlled delivery of siRNA from biodegradable tissue regenerative scaffolds.</b> Therapeutic application of this approach to silence prolyl hydroxylase domain 2 promoted expression of pro-angiogenic genes controlled by HIF1α and enhanced scaffold vascularization <i>in vivo</i>. This technology provides a new standard for efficient and controllable gene silencing to modulate host response within regenerative biomaterials.
Medical subject headings
- Drug Carriers
- Neovascularization, Physiologic
- RNA, Small Interfering
- Tissue Scaffolds