Antitags: SERS-encoded nanoparticle assemblies that enable single-spot multiplex protein detection.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24338905.
- Also identified by DOI 10.1002/adma.201304107.
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Abstract
Simultaneous detection of multiple proteins on a single spot can be efficiently achieved by using multiplexed surface-enhanced Raman spectroscopy (SERS)-encoded nanoparticle 'antitags' consisting of poly(ethylene glycol) (PEG)-protected silver dimers (and higher aggregates) and antibody-tagging entities. The effective SERS-based multivariate deconvolution approach guarantees an accurate and successful distinguishable identification of single and multiple proteins in complex samples. Their potential application in multiplexed SERS bioimaging technology can be easily envisaged.
Medical subject headings
- Metal Nanoparticles
- Polyethylene Glycols
- Proteins
- Silver Compounds
- Spectrum Analysis, Raman