Whole blood cells loaded with messenger RNA as an anti-tumor vaccine.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24339387.
- Also identified by DOI 10.1002/adhm.201300512 and PMC identifier 4053491.
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Abstract
The use of a cell-based vaccine composed of autologous whole blood cells loaded with mRNA is described. Mice immunized with whole blood cells loaded with mRNA encoding antigen develop anti-tumor immunity comparable to DC-RNA immunization. This approach offers a simple and affordable alternative to RNA-based cellular therapy by circumventing complex, laborious and expensive ex vivo manipulations required for DC-based immunizations.
Medical subject headings
- Blood Cells
- Cancer Vaccines
- RNA, Messenger