Structural insights into RbmA, a biofilm scaffolding protein of V. cholerae.
basic_science · Level V
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- Record sourced from PubMed, PMID 24340031.
- Also identified by DOI 10.1371/journal.pone.0082458 and PMC identifier PMC1304786.
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Abstract
V. cholerae can form sessile biofilms associated with abiotic surfaces, cyanobacteria, zoo-plankton, mollusks, or crustaceans. Along with the vibrio polysaccharide, secreted proteins of the rbm gene cluster are key to the biofilm ultrastructure. Here we provide a thorough structural characterization of RbmA, a protein involved in mediating cell-cell and cell-biofilm contacts. We correlate our structural findings with initial ligand specificity screening results, NMR protein-ligand interaction analysis, and complement our results with a full biocomputational study.