Structure of a photosynthetic reaction centre determined by serial femtosecond crystallography.

Johansson, Linda C; Arnlund, David; Katona, Gergely; White, Thomas A; Barty, Anton; DePonte, Daniel P; Shoeman, Robert L; Wickstrand, Cecilia et al. · Nat Commun · 2013

basic_science · Level V

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Abstract

Serial femtosecond crystallography is an X-ray free-electron-laser-based method with considerable potential to have an impact on challenging problems in structural biology. Here we present X-ray diffraction data recorded from microcrystals of the Blastochloris viridis photosynthetic reaction centre to 2.8 Å resolution and determine its serial femtosecond crystallography structure to 3.5 Å resolution. Although every microcrystal is exposed to a dose of 33 MGy, no signs of X-ray-induced radiation damage are visible in this integral membrane protein structure.

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