A multi-modality platform to image stem cell graft survival in the naïve and stroke-damaged mouse brain.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24355489.
- Also identified by DOI 10.1016/j.biomaterials.2013.11.085.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Neural stem cell implantations have been extensively investigated for treatment of brain diseases such as stroke. In order to follow the localization and functional status of cells after implantation noninvasive imaging is essential. Therefore, we developed a comprehensive multi-modality platform for in vivo imaging of graft localization, density, and survival using 19F magnetic resonance imaging in combination with bioluminescence imaging. We quantitatively analyzed cell graft survival over the first 4 weeks after transplantation in both healthy and stroke-damaged mouse brain and correlated our findings of graft vitality with the host innate immune response. The multi-modality imaging platform will help to improve cell therapy also in context other than stroke and to gain indispensable information for clinical translation.
Medical subject headings
- Brain
- Graft Survival
- Stem Cell Transplantation
- Stroke