Probing DNA by 2-OG-dependent dioxygenase.
basic_science · Level V
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- Record sourced from PubMed, PMID 24360270.
- Also identified by DOI 10.1016/j.cell.2013.12.002 and PMC identifier 3916139.
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Abstract
TET-mediated 5-methyl cytosine (5mC) oxidation acts in epigenetic regulation, stem cell development, and cancer. Hu et al. now determine the crystal structure of the TET2 catalytic domain bound to DNA, shedding light on 5mC-DNA substrate recognition and the catalytic mechanism of 5mC oxidation.
Medical subject headings
- 5-Methylcytosine
- DNA
- DNA-Binding Proteins
- Proto-Oncogene Proteins