Metabolic thrift and the genetic basis of human obesity.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 24368636.
- Also identified by DOI 10.1097/SLA.0000000000000361 and PMC identifier 4057799.
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Abstract
Evolution has molded metabolic thrift within humans, a genetic heritage that, when thrust into our modern "obesogenic" environment, creates the current obesity crisis. Modern genetic analysis has identified genetic and epigenetic contributors to obesity, an understanding of which will guide the development of environmental, pharmacologic, and genetic therapeutic interventions.
Medical subject headings
- Biological Evolution
- Energy Metabolism
- Genetic Predisposition to Disease
- Obesity