PEGylated WS(2) nanosheets as a multifunctional theranostic agent for in vivo dual-modal CT/photoacoustic imaging guided photothermal therapy.
basic_science · Level V
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- Record sourced from PubMed, PMID 24375758.
- Also identified by DOI 10.1002/adma.201304497.
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Abstract
A new generation of photothermal theranostic agents is developed based on PEGylated WS2 nanosheets. Bimodal in vivo CT/photoacoustic imaging reveals strong tumor contrast after either intratumoral or intravenous injection of WS2 -PEG. In vivo photothermal treatment is then conducted in a mouse tumor model, achieving excellent therapeutic efficacy with complete ablation of tumors. This work promises further exploration of transition-metal dichalcogenides for biomedical applications, such as cancer imaging and therapy.
Medical subject headings
- Nanostructures
- Phototherapy
- Polyethylene Glycols
- Tungsten Compounds