Endocytic pH-triggered degradation of nanoengineered multilayer capsules.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24375946.
- Also identified by DOI 10.1002/adma.201305144.
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Abstract
The synthesis of cross-linker free layer-by-layer (LbL) capsules that solely utilize cellular pH variations as a trigger to specifically deconstruct and subsequently release cargo in cells is reported. These capsules demonstrate retention of water-soluble therapeutic molecules as small as 500 Da at extracellular pH. Triggered capsule degradation and release of cargo is observed within 30 min of cell uptake.
Medical subject headings
- Drug Carriers
- Intracellular Space
- Nanocapsules