Heat-shock protein-70 and regulatory T cell-mediated protection from ischemic injury.
Level V
Where this comes from
- Record sourced from PubMed, PMID 24380899.
- Also identified by DOI 10.1038/ki.2013.304.
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Abstract
Heat preconditioning induces heat-shock protein-70 upregulation and protects from renal ischemia/reperfusion injury. Kim et al. report that heat-shock protein-70 and regulatory T cells play a key role in protective heat preconditioning. This work reinforces the utility of inducing heat-shock protein-70 expression by pharmacological agents as a novel therapy for the prevention and treatment of ischemic kidney injury.
Medical subject headings
- Acute Kidney Injury
- HSP70 Heat-Shock Proteins
- Reperfusion Injury
- T-Lymphocytes, Regulatory