In and out of the bone: can the osteocyte escape skeletal jail and yet regulate mineralization?
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24380901.
- Also identified by DOI 10.1038/ki.2013.296.
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Abstract
An increase in the levels of fibroblast growth factor 23 (FGF23) develops in the early phase of chronic kidney disease (CKD). However, the initial trigger of CKD-mineral and bone disorder (CKD-MBD) is a matter of debate. Fang and associates provide evidence, in a mouse model of early CKD, that osteocytes and osteocyte-like cells play an important role at the earliest stage of CKD-MBD. The osteocytes may become a target of intervention in CKD-MBD.
Medical subject headings
- Bone Diseases, Metabolic
- Fibroblast Growth Factors
- Glucuronidase
- Renal Insufficiency, Chronic
- Vascular Calcification