Characterizing DNA methylation alterations from The Cancer Genome Atlas.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 24382385.
- Also identified by DOI 10.1172/JCI69740 and PMC identifier 3871233.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The Cancer Genome Atlas (TCGA) Research Network is an ambitious multi-institutional consortium effort aimed at characterizing sequence, copy number, gene (mRNA) expression, microRNA expression, and DNA methylation alterations in 30 cancer types. TCGA data have become an extraordinary resource for basic, translational, and clinical researchers and have the potential to shape cancer diagnostic and treatment strategies. DNA methylation changes are integral to all aspects of cancer genomics and have been shown to have important associations with gene expression, sequence, and copy number changes. This Review highlights the knowledge gained from DNA methylation alterations in human cancers from TCGA.
Medical subject headings
- DNA Methylation
- Epigenesis, Genetic
- Neoplasms