HSPCs get their motors running for asymmetric fate choice.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24388168.
- Also identified by DOI 10.1016/j.stem.2013.12.002 and PMC identifier 3916825.
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Abstract
Contractile forces are implicated in cell polarity and asymmetric division, but their contribution to cell fate is unclear. In this issue of Cell Stem Cell, Shin et al. (2014) show that myosin-II isoforms sense matrix stiffness in hematopoietic stem and progenitor cells, with polarized myosin-IIB promoting asymmetric self-renewal and constitutive myosin-IIA activation promoting cytokine-triggered differentiation.
Medical subject headings
- Cell Differentiation
- Cell Movement
- Hematopoiesis
- Hematopoietic Stem Cells
- Muscle Contraction
- Nonmuscle Myosin Type IIA
- Nonmuscle Myosin Type IIB